Expression optimization
for any tissue, any organism:
SuRE™ promoters
AIM™ integration sites
Bespoke qualified promoters for controlled gene expression in cell and gene therapy or protein and virus production.
Identification of optimal genomic integration sites for cell therapy and manufacturing cell lines.
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Introducing our experts
We have a team of highly skilled and enthusiastic scientists and technicians dedicated to our clients projects. In addition, they work on new developments around our SuRE™ platform to ensure its continuous improvement for pharmaceutical and agricultural applications. The team is led by founder Joris van Arensbergen and biotech entrepreneur Victor Schut.
Recent News & Events
BLOG
Insights blog - April 2024
Considerations for developing safe and effective gene therapies: promoters
To improve safety and effectiveness of gene therapies, manufacturers can adjust three principal components: the therapeutic gene, the viral vector (including viral capsid) and the promoter. In this blog, we share insights from both recent publications and customer insights on how the latter element, promoters, are the next frontier in fine tuning and improving ATMP effectiveness.
NEWS
News - April 2024
Annogen Announces Research Collaboration for the Development of Cell Specific Promoters for Undisclosed Cell Therapy Company
Annogen announced a research collaboration for the identification of immune cell specific promoters for the use in a new cell therapy program for an undisclosed company. The developed regulatory elements will aid in developing safe and effective autologous T-cell therapies.
UPDATES
Updates - December 2023
Annogen signs deal in which SuRE™ libraries are used for in-vivo capsid screening
Annogen has signed a deal with an undisclosed gene therapy company for an AAV capsid screening project. For this project Annogen will deliver its SuRE™ barcoding platform and downstream bioinformatics analysis to track tissue-specific biases for many capsids in parallel.
UPDATES
Updates - October 2023
Annogen introduces HEK293-INDX1™ - a clonal HEK293 cell line for inducible expression of toxic proteins such as Rep during AAV production
Annogen is excited to share our latest breakthrough in cellular engineering. We've successfully combined our SuRE™ promoter screening platform and our AIM™ integration site screening platform to establish HEK293 clones with near-zero baseline expression and high inducibility with added stimulus.
EVENTS
Events - Annogen attending BIOEurope in Munich, November 6–8, 2023
Request a partnering meeting with P. Victor Schut, CBO (victor@annogen.bio) and discuss the applications of:
- SuRE™ human promoters for cell and gene therapy
- CHO genome derived promoters for protein manufacturing, cell culture, and
- AIM™ integration site mapping for cell engineering (allogeneic, cell therapy and cell line generation).
EVENTS
Events - Annogen attending the virtual partnering at Alliance for Regenerative Medicine, October 17-18, 2023
Annogen plays a specific role in providing its SuRE™ human promoters (cell specific and/or inducible) and AIM™ integration mapping for cell engineering (e.g. allogeneic platforms).
Looking forward to connecting with senior executives and top stakeholders to tackle the most pressing issues in cell and gene therapies. Please contact (victor@annogen.bio) to learn more about the Annogen qualified promoters and cell engineering capabilities.
NEWS
PRESS RELEASE - April 2022 Annogen signs another collaboration agreement with a Tier 1 agricultural firm to research non-coding regulatory DNA using SuRE™ screening technology.
Annogen, the Amsterdam based biotech company behind the SuRE™ technology for the functional annotation of the non-coding part of the genome, started a collaboration with a Tier 1 agri firm to test non-coding DNA fragments that are predicted to influence the expression of important crop traits. The results are expected to provide possibilities to intentionally upregulate or downregulate the expression of important genes in crops.
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